When a physics professor at a major U.S. university steals weaponized uranium, the team scrambles to find the professor and the missing uranium before it can be used against an important international summit meeting in New York City.
- Priyanka Chopra as Alex Parrish
- Jake McLaughlin as Ryan Booth
- Johanna Braddy as Shelby Wyatt
- Russell Tovey as Harry Doyle
- Blair Underwood as Owen Hall
- Marlee Matlin as Jocelyn Turner
- Alan Powell as Mike McQuigg
- Amber Skye Noyes as Celine Fox
- Vandit Bhatt as Jagdeep Patel
- Jessica Hecht as Elizabeth Nutting
- Babak Tafti as Adnan Hamza
- Rosa Arredondo as Director Carmella Gomez
- The title of the episode was confirmed from a Twitter update by the third season show runner, Michael Seitzman.